Loss of BRCA1-associated protein 1 (BAP1) expression is useful in diagnostic cytopathology of malignant mesothelioma in effusions.

Ilaria CozziFlorina Anca OprescuEmma RulloValeria Ascoli

Published in: Diagnostic cytopathology (2017)

In effusions with mesotheliomatous cells or atypical mesothelial cells of uncertain significance, negative BAP1 IHC strongly supports a diagnosis of MM. With prudence in interpreting immunostaining, BAP1 may be included in IHC panels for MM cytodiagnosis, given its high specificity and sensitivity.

Keyphrases

induced apoptosis
cell cycle arrest
poor prognosis
signaling pathway
oxidative stress
cell proliferation
binding protein
long non coding rna
pi k akt