In Vitro Lipid Overload Affects Cellular Proliferation, Apoptosis, and Senescence in a Time-Dependent Manner in HepG2 Hepatocytes and LX-2 Hepatic Stellate Cells.
Adriana Campos-EspinosaCarolina GuzmánKarla Zaira Medina-ÁvilaGabriela Gutierrez-ReyesPublished in: Cells (2024)
Lipid overload induces differential effects depending on the cell type, the steatogenic input level, and the exposure time. Hepatocytes are resilient to mild steatosis but susceptible to high lipotoxicity. HSCs are sensitive to lipid overload, undergoing apoptosis and lowering senescence and proliferation. Collectively, these data may help explain the development of steatosis and fibrosis in SLD.
Keyphrases
- cell cycle arrest
- endoplasmic reticulum stress
- cell death
- induced apoptosis
- oxidative stress
- signaling pathway
- pi k akt
- insulin resistance
- fatty acid
- dna damage
- high fat diet
- endothelial cells
- liver injury
- stress induced
- high fat diet induced
- electronic health record
- drug induced
- adipose tissue
- type diabetes
- metabolic syndrome
- skeletal muscle
- machine learning