The Effect of Endothelin Receptor Antagonists in Patients with Eisenmenger Syndrome: A Systematic Review.
Abdelrahman ElshafayDuy Hieu TruongMohamed M AboElnasHossam IdreesHatem G MetwaliNguyen Lam VuongOmar Ahmed SaadKenji HirayamaNguyen Tien HuyPublished in: American journal of cardiovascular drugs : drugs, devices, and other interventions (2018)
This study demonstrated safety and improved hemodynamic effects of bosentan in ES, with a controversial effect on exercise capacity. Further randomized controlled trials with longer follow-up duration are needed to confirm these results.