Checkpoint-blocker-induced autoimmunity is associated with favourable outcome in metastatic melanoma and distinct T-cell expression profiles.

Weiyu YeAnna Olsson-BrownRobert A WatsonVincent T F CheungRobert D MorganIsar NassiriRosalin CooperChelsea A TaylorUmair AkbaniOliver BrainRubeta N MatinNicholas Coupe Mark Ross MiddletonMark ColesJoseph J SaccoMiranda J PayneBenjamin P Fairfax

Published in: British journal of cancer (2021)

Early irAE development post-ICB is associated with favourable survival in MM. Development of irAEs is coupled to expression of numerous gene pathways, suggesting irAE development in-part reflects baseline immune activation.

Keyphrases

poor prognosis
dna damage
gene expression
copy number
genome wide
cell proliferation
diabetic rats
oxidative stress
dna methylation
binding protein
stress induced