Human-induced pluripotent stem cell-derived hepatocyte platform in modeling of SARS-CoV-2 infection.

Ruiqi ZhangRui WeiYangyang YuanNa LiYang HuKwok-Hung ChanIvan Fan-Ngai HungHung-Fat Tse

Published in: JGH open : an open access journal of gastroenterology and hepatology (2024)

The iPSC-derived hepatocytes can support the replication of SARS-CoV-2, and this platform could be used to investigate the SARS-CoV-2 hepatotropism and hepatic pathogenic mechanisms.

Keyphrases

sars cov
respiratory syndrome coronavirus
induced pluripotent stem cells
endothelial cells
liver injury
drug induced
high glucose
high throughput
diabetic rats
pluripotent stem cells