'Snail factors in testicular germ cell tumours and their regulation by the BMP4 signalling pathway'.
Diana J MicatiKarthika RadhakrishnanJulia C YoungEwa Rajpert-De MeytsGary R HimeHelen E AbudKate L LovelandPublished in: Andrology (2020)
This is the first evidence that SNAI1 and SNAI2 are involved in human spermatogenesis, with independent functions. These outcomes demonstrate that SNAI1 and SNAI2 inhibition leads to loss of migratory and viability capacities in seminoma cells. These findings show the potential for therapeutic treatments targeting SNAIL or BMP4 signalling for patients with metastatic testicular germ cell tumours.
Keyphrases
- germ cell
- epithelial mesenchymal transition
- mesenchymal stem cells
- induced apoptosis
- endothelial cells
- cell cycle arrest
- bone regeneration
- induced pluripotent stem cells
- type diabetes
- endoplasmic reticulum stress
- metabolic syndrome
- oxidative stress
- skeletal muscle
- cell proliferation
- human health
- pluripotent stem cells
- insulin resistance