The Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure with Preserved Ejection Fraction (SPIRRIT-HFpEF): Rationale and design.

Lars H LundStefan JamesAdam D DeVoreKevin J AnstromMarat FudimKeith D AaronsonUlf DahlströmPatrice Desvigne-NickensJerome L FlegSong YangMichael FuCamilla HageClaes HeldPatric KarlströmMagnus NygrenEric D PetersonTymon PolShelly SappJohan SundströmOllie ÖstlundJonas OldgrenBertram Pitt

Published in: European journal of heart failure (2024)

SPIRRIT-HFpEF will be informative on the effectiveness of generic MRAs in HFpEF and HFmrEF, and on the feasibility of conducting pragmatic and registry-based trials in heart failure and other chronic conditions.

Keyphrases

phase iii
heart failure
study protocol
phase ii
open label
randomized controlled trial
double blind
clinical trial
placebo controlled
systematic review
left ventricular