A potential contribution of decreased galectin-7 expression in stratified epithelia to the development of cutaneous and oesophageal manifestations in systemic sclerosis.

Ryosuke SaigusaTakashi YamashitaShunsuke MiuraMegumi HirabayashiKouki NakamuraTakuya MiyagawaYuki FukuiAyumi YoshizakiShinichi SatoYoshihide Asano

Published in: Experimental dermatology (2020)

Galectin-7 downregulation in stratified epithelia, which is mediated at least partially by autocrine endothelin stimulation, may contribute to the development of cutaneous manifestations and oesophageal dysfunction in SSc patients.

Keyphrases

systemic sclerosis
end stage renal disease
interstitial lung disease
newly diagnosed
chronic kidney disease
ejection fraction
poor prognosis
cell proliferation
peritoneal dialysis
signaling pathway
long non coding rna
idiopathic pulmonary fibrosis