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A rhodium(iii)-catalyzed tunable coupling reaction of indole derivatives with alkylidenecyclopropanes via C-H activation.

Ruixing LiuYin WeiMin Shi
Published in: Chemical communications (Cambridge, England) (2019)
We herein report a rhodium(iii)-catalyzed cross coupling of indole derivatives with alkylidenecyclopropanes (ACPs) in the presence of KCl, affording the alkene products exclusively with E-selectivity via C-H bond activation. The beta-H elimination to afford the conjugated diene derivatives has been suppressed by the addition of KCl. A plausible reaction mechanism has been proposed along with derivatization of the obtained product to demonstrate the practical usefulness of this synthetic protocol.
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