Interleukin-10 from CD4+ follicular regulatory T cells promotes the germinal center response.
Brian J LaidlawYisi LuRobert A AmezquitaJason S WeinsteinJason A Vander HeidenNamita T GuptaSteven H KleinsteinSusan M KaechJoseph E CraftPublished in: Science immunology (2018)
CD4+ follicular regulatory T (Tfr) cells suppress B cell responses through modulation of follicular helper T (Tfh) cells and germinal center (GC) development. We found that Tfr cells can also promote the GC response through provision of interleukin-10 (IL-10) after acute infection with lymphocytic choriomeningitis virus (LCMV). Sensing of IL-10 by B cells was necessary for optimal development of the GC response. GC B cells formed in the absence of Treg cell-derived IL-10 displayed an altered dark zone state and decreased expression of the transcription factor Forkhead box protein 1 (FOXO1). IL-10 promoted nuclear translocation of FOXO1 in activated B cells. These data indicate that Tfr cells play a multifaceted role in the fine-tuning of the GC response and identify IL-10 as an important mediator by which Tfr cells support the GC reaction.
Keyphrases
- induced apoptosis
- transcription factor
- regulatory t cells
- cell cycle arrest
- signaling pathway
- endoplasmic reticulum stress
- cell death
- palliative care
- cell proliferation
- gas chromatography
- dendritic cells
- oxidative stress
- machine learning
- artificial intelligence
- long non coding rna
- immune response
- big data
- deep learning
- electron transfer