miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1).

Jaekwang KimFabienne C FieselKrystal C BelmonteRoman HudecWang-Xia WangChaeyoung KimPeter T NelsonWolfdieter SpringerJungsu Kim

Published in: Molecular neurodegeneration (2016)

We demonstrated that miR-27a and miR-27b regulate PINK1 expression and autophagic clearance of damaged mitochondria. Our data further support a novel negative regulatory mechanism of PINK1-mediated mitophagy by miR-27a and miR-27b. Therefore, our results considerably advance our understanding of PINK1 expression and mitophagy regulation and suggest that miR-27a and miR-27b may represent potential therapeutic targets for PD.

Keyphrases

cell proliferation
long non coding rna
poor prognosis
cell death
long noncoding rna
binding protein
reactive oxygen species
diabetic rats
machine learning
endothelial cells
risk assessment
endoplasmic reticulum
tyrosine kinase
climate change
drug induced
artificial intelligence