Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: results of the CHIC study.
Josef S SmolenRémy L M MostardCésar Magro-ChecaChristel M P van DongenTom DormansJacqueline BuijsMichiel GronenschildMartijn D de KruifEric H J van HarenTom van KraaijMathie P G LeersRalph PeetersDennis R WongRobert B M LandewePublished in: Annals of the rheumatic diseases (2020)
A strategy involving a course of high-dose methylprednisolone, followed by tocilizumab if needed, may accelerate respiratory recovery, lower hospital mortality and reduce the likelihood of invasive mechanical ventilation in COVID-19-associated CSS.
Keyphrases
- mechanical ventilation
- high dose
- rheumatoid arthritis
- acute respiratory distress syndrome
- healthcare
- intensive care unit
- coronavirus disease
- juvenile idiopathic arthritis
- sars cov
- rheumatoid arthritis patients
- stem cell transplantation
- palliative care
- respiratory failure
- cardiovascular events
- disease activity
- adverse drug
- type diabetes
- case report
- extracorporeal membrane oxygenation
- emergency department
- cardiovascular disease
- pain management
- respiratory syndrome coronavirus