A novel long non-coding RNA XLOC_004787, is associated with migration and promotes cancer cell proliferation by downregulating mir-203a-3p in gastric cancer.
Renjie MiaoZhendong YaoBingheng HuTao JinDonglai ZhuYun ShiYuhua GongShihe ShaoChen ShaoPublished in: BMC gastroenterology (2023)
These results suggest that XLOC_004787, found to be upregulated in GC tissues, potentially promotes proliferation and migration in GC cells. This occurs through the activation of TGF-β and Wnt/β-catenin signaling pathways and the expression of EMT-related proteins. Additionally, XLOC_004787 may influence cell migration and proliferation by modulating the signaling pathway via the adsorption and inhibition of mir-203a-3p.
Keyphrases
- signaling pathway
- long non coding rna
- induced apoptosis
- poor prognosis
- epithelial mesenchymal transition
- cell proliferation
- cell migration
- pi k akt
- cell cycle arrest
- transforming growth factor
- papillary thyroid
- cell cycle
- stem cells
- gene expression
- endoplasmic reticulum stress
- cell death
- mass spectrometry
- squamous cell
- binding protein
- lymph node metastasis