Early Changes in Nutritional Status of Elderly Patients with Lung Cancer Undergoing Chemotherapy Are Positively Related with Symptoms of Depression: A Prospective Follow-Up Study.
Wioleta UmławskaKatarzyna Pawłowska-SeredyńskaMalwina GoździkIrena PorębskaPublished in: Nutrition and cancer (2024)
This study aims to assess early effects of chemotherapy on symptom alleviation, nutritional status, and mental health in elderly patients with advanced non-small-cell lung cancer (NSCLC). This prospective study included 45 NSCLC patients (32 males, 13 females) aged 65-82 years (mean age 70.0 ± 4.5 years) with good performance status. Assessments were conducted immediately after diagnosis and after two chemotherapy cycles, focusing on nutritional status (assessed with MNA questionnaire), quality of life (QoL, based on FACT-L and FACT-TOI questionnaires), lung cancer-related symptoms (based on LCSS), and mental health (based on PHQ-9 questionnaire). Despite significant alleviation of symptoms like cough, dyspnea, and body weight loss, there was no significant correlation between changes in symptoms burden and changes in nutritional status ( r 2 = 0.122, P = 0.427), and change of patients' mental condition ( r 2 = -0.141, P = 0.255). No significant QoL changes were noted, but a decrease in severe depression frequency was observed. The improvement of patients' mental condition was related strictly to the improvement of nutritional status ( r 2 = -0.589, P < 0.001). The study highlights the vital link between nutritional status and mental health in elderly NSCLC patients, emphasizing the need for integrated care approaches that address both aspects to enhance treatment effectiveness and patient well-being.
Keyphrases
- mental health
- end stage renal disease
- advanced non small cell lung cancer
- newly diagnosed
- ejection fraction
- chronic kidney disease
- prognostic factors
- small cell lung cancer
- weight loss
- peritoneal dialysis
- type diabetes
- healthcare
- sleep quality
- systematic review
- radiation therapy
- bariatric surgery
- physical activity
- mental illness
- patient reported outcomes
- cross sectional
- chronic pain
- case report
- locally advanced
- epidermal growth factor receptor
- drug induced
- smoking cessation