Enhanced small neutral but not branched chain amino acid transport after epigenetic sodium coupled neutral amino acid transporter-2 (SNAT2) cDNA expression in myoblasts.

Timothy PearsonOskar WendowskiPenny P Powell

Published in: Journal of cachexia, sarcopenia and muscle (2021)

Overall, these data show that transfection of SNAT2-eGFP expression enhanced its function following starvation and treatment with physiological levels of DHT. Enhanced SNAT2 expression in muscle cells offers a viable epigenetic target in pathological conditions associated with altered amino acid transport.

Keyphrases

amino acid
poor prognosis
dna methylation
gene expression
binding protein
induced apoptosis
skeletal muscle
cell proliferation
cell death
electronic health record
oxidative stress
cell cycle arrest
signaling pathway
replacement therapy
pi k akt