Adipocyte-specific Repression of PPAR-gamma by NCoR Contributes to Scleroderma Skin Fibrosis.

Benjamin D KormanRoberta Goncalves MarangoniGabriel LordJerrold OlefskyWarren TourtellotteJohn Varga

Published in: Arthritis research & therapy (2018)

Our results implicate, for the first time, to our knowledge, deregulated NCoR/PPAR-γ pathways in SSc, and they support a role of adipocyte modulation of skin fibrosis. Pharmacologic restoration of NCoR/PPAR-γ signaling may represent a novel strategy to control skin fibrosis in SSc.

Keyphrases

insulin resistance
fatty acid
soft tissue
adipose tissue
wound healing
healthcare
systemic sclerosis
metabolic syndrome
skeletal muscle
liver fibrosis