Bromhexine Hydrochloride Prophylaxis of COVID-19 for Medical Personnel: A Randomized Open-Label Study.
Evgeny N M MikhaylovTamara A LyubimtsevaAleksandr D VakhrushevDmitry StepanovDmitry S LebedevElena Yu VasilievaAlexandra Olegovna KonradiEvgeny V ShlyakhtoPublished in: Interdisciplinary perspectives on infectious diseases (2022)
Although the study was underpowered, it showed that Bromhexine hydrochloride prophylaxis was associated with a reduced rate of symptomatic COVID-19. The prophylactic treatment was not associated with a lower combined primary endpoint rate, a positive swab PCR test, or COVID-19 (ClinicalTrials.gov number, NCT04405999).