Expansion of epigenetic alterations in EFEMP1 promoter predicts malignant formation in pancreatobiliary intraductal papillary mucinous neoplasms.

Kazuhiro YoshidaTakeshi NagasakaYuzo UmedaTakehiro TanakaKeisuke KimuraFumitaka TaniguchiTomokazu FujiKunitoshi ShigeyasuYoshiko MoriHiroyuki YanaiTakahito YagiAjay GoelToshiyoshi Fujiwara

Published in: Journal of cancer research and clinical oncology (2016)

Extensive methylation of the EFEMP1 gene promoter can discriminate invasive from benign IPMNs with superior accuracy owing to their stepwise accumulation of tumor progression.

Keyphrases

dna methylation
genome wide
gene expression
copy number
transcription factor
poor prognosis
low grade
clear cell