Myofibroblast-Specific Msi2 Knockout Inhibits HCC Progression in a Mouse Model.

Chen QuLu HeNan YaoJinying LiYuchuan JiangBin-Kui LiShuang PengKunpeng HuDong ChenGuo ChenWei HuangMingrong CaoJun FanYunfei YuanWencai YeJian Hong

Published in: Hepatology (Baltimore, Md.) (2022)

Myofibroblast-specific Msi2 knockout abrogated the tumor-promoting function of myofibroblasts and inhibited HCC progression in mouse models. Targeting myofibroblast MSI2 expression may therefore prove to be a therapeutic strategy for HCC treatment in the future.

Keyphrases

mouse model
transforming growth factor
pulmonary fibrosis
poor prognosis
current status
combination therapy
long non coding rna