Sustained hyperosmolarity increses TGF-ß1 and Egr-1 expression in the rat renal medulla.

Miklós M MózesPetra SzoleczkyLászló RosivallGábor Kökény

Published in: BMC nephrology (2017)

We conclude that both TGF-ß and Egr-1 are upregulated by sustained hyperosmolarity in the rat renal medulla, and it favors the expression of extracellular matrix components.

Keyphrases

extracellular matrix
poor prognosis
transforming growth factor
oxidative stress
binding protein
signaling pathway