Rationale and protocol of the LAQUA-HF trial: a factorial randomised controlled trial evaluating the effects of neurohormonal and diuretic agents on health-status reported outcomes in heart failure patients.

Yasuyuki Shiraishi Nobuhiro IkemuraMitsuyoshi UrashimaTakashi KohnoShintaro NakanoToshikazu TanakaYuji NagatomoTakenori IkomaTomohiko OnoYohei NumasawaMunehisa SakamotoKei NishikawaMakoto TakeiDaihiko HakunoRyo NakamaruIkuko UedaShun Kohsaka

Published in: BMJ open (2024)

UMIN000045229.

Keyphrases

study protocol
randomized controlled trial
acute heart failure
clinical trial
phase iii
ejection fraction
phase ii
open label
heart failure
type diabetes
metabolic syndrome
atrial fibrillation
skeletal muscle
placebo controlled
insulin resistance
weight loss