PRAMEF12 , a novel cancer/testis gene, regulates proliferation and apoptosis to promote progression of glioma.
Jiaqiang LiJianhua ZhongAifa TangJianchun YinShoulin LiPublished in: Biomarkers in medicine (2024)
Aim: To evaluate whether PRAMEF12 can serve as a diagnostic biomarker for glioma. Methods: We examined PRAMEF12 expression in multiple normal and glioma tissues. The diagnostic value of PRAMEF12 was evaluated using receiver operating characteristic curve analysis. The effect of PRAMEF12 ablation on proliferation, cell cycle and apoptosis was investigated. Database analyses were utilized for functional enrichment analysis. Results: PRAMEF12 expression in normal tissue was restricted to the human testis. PRAMEF12 displayed significant diagnostic value in glioma. PRAMEF12 knockdown inhibited cell proliferation, induced apoptosis and resulted in induction of S-phase cell cycle arrest. Pathway enrichment analysis indicated that PRAMEF12 may participate in cancer. Conclusion: PRAMEF12 , a novel cancer/testis gene, may be a potential new diagnostic biomarker for glioma.
Keyphrases
- cell cycle arrest
- cell cycle
- cell proliferation
- induced apoptosis
- endoplasmic reticulum stress
- papillary thyroid
- cell death
- oxidative stress
- signaling pathway
- poor prognosis
- pi k akt
- squamous cell
- endothelial cells
- genome wide
- gene expression
- emergency department
- squamous cell carcinoma
- copy number
- binding protein
- dna methylation
- high resolution
- atrial fibrillation
- electronic health record
- childhood cancer
- atomic force microscopy
- radiofrequency ablation