Impact of FCGR2A R131H, FCGR3A F158V and FCGR3B NA1/NA2 polymorphisms on response to fc-containing TNF inhibitors in Tunisian rheumatoid arthritis patients.

Mahmoud InesMyriam MoallaBen Tekaya AichaBouden SelmaRouached LeilaTekaya RawdhaSaidane OlfaGorji YousrElleuch MohamedLaatar AhmedHamdi WafaAbdelmoula LeilaSfar Imen

Published in: Drug metabolism and personalized therapy (2023)

Identifying reliable biomarkers of response to biologics in RA is necessary to improve responsiveness, preserve joints' functions and structure, and reduce treatment's cost. Our study showed that FCGR3A and FCGR3B polymorphisms might have an impact on TNFis' response in RA Tunisian patients since bad response was more frequent in homozygous carriers of high affinity alleles FCGR3A-V and FCGR3B-NA1.

Keyphrases

rheumatoid arthritis patients
rheumatoid arthritis
disease activity
end stage renal disease
ejection fraction
newly diagnosed
peritoneal dialysis
prognostic factors
ankylosing spondylitis
systemic lupus erythematosus
idiopathic pulmonary fibrosis
patient reported outcomes
smoking cessation