Profiling of Androgen-Dependent Enhancer RNAs Expression in Human Prostate Tumors: Search for Malignancy Transition Markers.

Koichi NishimuraJinichi MoriTakahiro SawadaShuhei NomuraAlexander KouzmenkoKaori YamashitaYoshiaki KanemotoTomohiro KurokawaAkira HayakawaSuguru TokiwaMichihisa OchiHiroaki ShimmuraShigeaki Kato

Published in: Research and reports in urology (2021)

Presented data suggest that prostate tumor development may associate with epigenetic reorganization in the KLK3 genomic regulatory elements reflected by changes of the KLK3eRNA expression. Our findings support a potential of eRNAs profiling to be used as diagnostic marker.

Keyphrases

poor prognosis
prostate cancer
binding protein
endothelial cells
transcription factor
benign prostatic hyperplasia
single cell
dna methylation
gene expression
copy number
machine learning
induced pluripotent stem cells
human health
climate change
data analysis