Slc26a3 deletion alters pH-microclimate, mucin biosynthesis, microbiome composition and increases the TNFα expression in murine colon.

Archana KiniAnurag K SinghBrigitte RiedererInes YangXinjie TanGabriella di StefanoQinghai TanFang XiaoWeiliang XiaSebastian SuerbaumUrsula E Seidler

Published in: Acta physiologica (Oxford, England) (2020)

These findings may explain the strong increase in the susceptibility of slc26a3-/- mice to DSS damage, and offer insight into the mechanisms leading to an increased incidence of intestinal inflammation in CLD patients.

Keyphrases

end stage renal disease
oxidative stress
ejection fraction
poor prognosis
newly diagnosed
chronic kidney disease
rheumatoid arthritis
peritoneal dialysis
prognostic factors
risk factors
metabolic syndrome
binding protein
high fat diet induced