Potential induction of h yperkeratosis in r ats' c ervi by gentamicin via induction of oxidative s tress, i nflammation and a poptosis .
Walaa Yehia AbdelzaherMina Ezzat AttyaMohamed Ahmed Zeen El-DinAlaa Gamal El SataeHatem A MohamedRemon R RofaeilPublished in: Human & experimental toxicology (2024)
The present study aimed to identify the possible effect of gentamicin (GEN) in Rats' Cervi. Estradiol Valerate (EV) was used to induce cervical hyperkeratosis. GEN was administered in absence of EV. Serum and cervical GEN concentration were determined. Levels of malondialdehyde (MDA), total nitrites/nitrate (NOx), reduced glutathione (GSH), tumor necrosis factor-α (TNF-α), sirtuin type 1 (Sirt1) and nuclear factor (erythroid-derived 2)-like-2 factors (Nrf2) were measured in cervix tissue. Expression of BAX and Bcl2 were determined. Cervical histopathological examination was done. EV and GEN significantly increased MDA, NOx, TNF-α and BAX/Bcl2 ratio with decrease in GSH, Nrf2 and Sirt1 levels in cervical tissue. Histopathological picture of diffuse and marked hyperkeratosis was detected in EV and GEN groups. In conclusion, GEN-induced cervical hyperkeratosis via induction of oxidative stress, inflammation and apoptosis.
Keyphrases
- oxidative stress
- diabetic rats
- induced apoptosis
- nuclear factor
- rheumatoid arthritis
- ischemia reperfusion injury
- dna damage
- cell cycle arrest
- poor prognosis
- toll like receptor
- nitric oxide
- breast cancer cells
- cell proliferation
- immune response
- risk assessment
- fluorescent probe
- high glucose
- inflammatory response
- human health