Sexual dimorphisms of mRNA and miRNA in human/murine heart disease.

Masato TsujiTakanori KawasakiTakeru MatsudaTomio AraiSatoshi GojoJun K Takeuchi

Published in: PloS one (2017)

mRNA and miRNA transcriptome of normal and disease heart show significant sex differences, which might impact the cardiac homeostasis. Together this study provides the first comprehensive picture of the genome-wide program underlying the heart sexual dimorphisms, laying the foundation for gender specific treatment strategies.

Keyphrases

genome wide
mental health
heart failure
endothelial cells
dna methylation
binding protein
pulmonary hypertension
quality improvement
rna seq
induced pluripotent stem cells
single cell
heat stress
copy number
pluripotent stem cells