MASS cohort: Multicenter, longitudinal, and prospective study of the role of microbiome in severe pneumonia and host susceptibility.
Xin WeiLi GuoHongliu CaiSilan GuLingling TangYuxin LengMinghui ChengGuojun HeYijiao HanXindie RenBaoyue LinLongxian LvHuanzhang ShaoMingqiang WangHongyu WangDan DangShengfeng WangNan WangPeng ShenQianqian WangYinghe XuYongpo JiangNing ZhangXuwei HeXuntao DengMuhua DaiLin ZhongYonghui XiongYujie PanKankai TangFengqi LiuBin YangLili RenJianwei WangChao JiangLingtong HuangPublished in: iMeta (2024)
The MASS cohort comprises 2000 ICU patients with severe pneumonia, covering community-acquired pneumonia, hospital-acquired pneumonia, and ventilator-associated pneumonia, sourced from 19 hospitals across 10 cities in three provinces. A wide array of samples including bronchoalveolar lavage fluid, sputum, feces, and whole blood are longitudinally collected throughout patients' ICU stays. The cohort study seeks to uncover the dynamics of lung and gut microbiomes and their associations with severe pneumonia and host susceptibility, integrating deep metagenomics and transcriptomics with detailed clinical data.
Keyphrases
- community acquired pneumonia
- intensive care unit
- early onset
- healthcare
- end stage renal disease
- respiratory failure
- newly diagnosed
- chronic kidney disease
- mechanical ventilation
- cystic fibrosis
- mycobacterium tuberculosis
- cross sectional
- prognostic factors
- emergency department
- single cell
- electronic health record
- high resolution
- high throughput
- drug induced
- patient reported outcomes
- pulmonary tuberculosis
- acute respiratory distress syndrome
- extracorporeal membrane oxygenation