Transcription factor TEAD4 could activate PCSK9 to promote the stemness of STAD cells through FAM. These results added weight to the assumption that TEAD4/PCSK9 axis has the potential to be the therapeutic target that inhibits cancer stem cell in STAD.
Keyphrases
- cancer stem cells
- transcription factor
- fatty acid
- stem cells
- low density lipoprotein
- induced apoptosis
- epithelial mesenchymal transition
- cell cycle arrest
- squamous cell carcinoma
- single cell
- physical activity
- body mass index
- cell therapy
- weight loss
- cell death
- oxidative stress
- dna binding
- weight gain
- radiation therapy