PTCH1 gene variants rs357564, rs2236405, rs2297086 and rs41313327, mRNA and tissue expression in basal cell carcinoma patients from Western Mexico.

Marianela Zambrano-Román Jorge-Ramón Padilla-Gutiérrez Yeminia Valle José Francisco Munoz-Valle Elizabeth Guevara-Gutiérrez Diana Emilia Martínez-Fernández Emmanuel Valdés-Alvarado

Published in: Journal of clinical laboratory analysis (2024)

The studied PTCH1 variants may not be associated with BCC development in the Western Mexico population. The PTCH1 mRNA levels were lower in patients with BCC compared to the control group, but its protein was underexpressed in the tissue samples.

Keyphrases

copy number
binding protein
end stage renal disease
basal cell carcinoma
ejection fraction
chronic kidney disease
newly diagnosed
poor prognosis
peritoneal dialysis
prognostic factors
genome wide
gene expression
patient reported outcomes
transcription factor
amino acid