Multiomics links global surfactant dysregulation with airflow obstruction and emphysema in COPD.
Ventzislava A HristovaAlastair WatsonRaghothama ChaerkadyMatthew S GloverJodie AcklandBastian AngermanGraham BelfieldMaria G BelvisiHannah BurkeDoriana CelluraHoward W ClarkDamla EtalAnna FreemanAshley I HeinsonSonja HessMichael HühnEmily HallAlex MackayJens MadsenChristopher McCraeDaniel MuthasSteven NovickKristoffer OstridgeLisa ÖbergAdam PlattAnthony D PostleC Mirella SpallutoOuti VaaralaJunmin WangKarl J StaplesTom M A Wilkinsonnull nullPublished in: ERJ open research (2022)
Using a multiomics approach, we demonstrate, for the first time, global surfactant dysregulation in COPD that was associated with emphysema, giving new insights into potential mechanisms underlying the cause or consequence of disease.