Nuclear Klf4 accumulation is associated with cetuximab drug-resistance and predicts poor prognosis of nasopharyngeal carcinoma.

Xiqing LiZunlan ZhaoShijiang YiLei MaMing LiMingyue LiuYaping ZhangGuangzhi Liu

Published in: Journal of translational medicine (2018)

The prognosis of nasopharyngeal carcinoma was not significantly improved by cetuximab treatment when the Klf4 was highly expressed in the nucleus of nasopharyngeal carcinoma tissues. The expression of Klf4 in the nucleus can be used as a biomarker for predicting the effects of cetuximab treatment in nasopharyngeal carcinoma, which might be attributed to the H-RAS and PI3K mutations, leading to cetuximab resistance.

Keyphrases

poor prognosis
wild type
long non coding rna
metastatic colorectal cancer
locally advanced
transcription factor
gene expression
radiation therapy
replacement therapy