μ-opioid receptor agonist facilitates circulating tumor cell formation in bladder cancer via the MOR/AKT/Slug pathway: a comprehensive study including randomized controlled trial.
Xiaoqiang WangSong ZhangDi JinJiamei LuoYumiao ShiYiqi ZhangLingling WuYanling SongDiansan SuZhiying PanHaige ChenMing CaoChaoyong YangWeifeng YuJie TianPublished in: Cancer communications (London, England) (2023)
MORAs promoted BC metastasis by facilitating CTC formation. The EMT-CTC axis could be targeted for preventive measures during MORA treatment to inhibit the associated tumor metastasis or recurrence in BC patients.
Keyphrases
- circulating tumor
- circulating tumor cells
- randomized controlled trial
- end stage renal disease
- epithelial mesenchymal transition
- ejection fraction
- chronic kidney disease
- cell free
- newly diagnosed
- signaling pathway
- study protocol
- cell proliferation
- chronic pain
- single cell
- cell therapy
- pain management
- cancer therapy
- clinical trial
- free survival
- patient reported
- bone marrow
- combination therapy