Early and late pulmonary effects of nebulized LPS in mice: An acute lung injury model.
Natália de Souza Xavier CostaGabriel Ribeiro JúniorAdair Aparecida Dos Santos AlemanyLuciano BelottiDouglas Hidalgo ZatiMarcela Frota CavalcanteMariana Matera VerasSusan RibeiroEsper Georges KallásPaulo Hilário Nascimento SaldivaMarisa DolhnikoffLuiz Fernando Ferraz da SilvaPublished in: PloS one (2017)
We present a feasible, reproducible and non-invasive nebulized-LPS animal model that allows the assessment of both the acute and late phases of acute lung injury. The presence of lung remodeling with collagen deposition after 5 weeks makes it useful to study the pathophysiology, complications, and possible therapeutic intervention studies that aim to understand and reduce pulmonary fibrosis in the late phases of ALI.
Keyphrases
- inflammatory response
- lipopolysaccharide induced
- pulmonary fibrosis
- lps induced
- liver failure
- randomized controlled trial
- anti inflammatory
- pulmonary hypertension
- respiratory failure
- wound healing
- type diabetes
- case control
- gestational age
- hepatitis b virus
- metabolic syndrome
- acute respiratory distress syndrome
- preterm birth
- extracorporeal membrane oxygenation