Clinical Correlation of Adenoviral Load in the Respiratory Tract Measured by Digital PCR in Immunocompromised Children.
Diego R HijanoJose A FerrolinoJennifer HidingerJessica N BrazeltonZhengming GuSri SugandaHeather L GlasgowKim J AllisonMegan PetersonRonald H DallasGabriela MaronRandall T HaydenPublished in: Open forum infectious diseases (2023)
Immunocompromised patients can have life-threatening adenoviral infection. Viral load in blood and stool is commonly used to guide antiviral therapy. We developed and evaluated a digital polymerase chain reaction assay to quantify human adenovirus in the respiratory tract and showed that higher peak load correlates with disseminated infection, mechanical ventilation, and death.
Keyphrases
- respiratory tract
- mechanical ventilation
- respiratory failure
- end stage renal disease
- acute respiratory distress syndrome
- ejection fraction
- endothelial cells
- intensive care unit
- newly diagnosed
- chronic kidney disease
- young adults
- peritoneal dialysis
- prognostic factors
- high throughput
- stem cells
- induced pluripotent stem cells
- pluripotent stem cells
- cell therapy