GWAS-identified CCR1 and IL10 loci contribute to M1 macrophage-predominant inflammation in Behçet's disease.

Hiroto NakanoYohei KirinoMitsuhiro TakenoKana HigashitaniHideto NagaiRyusuke YoshimiYukie YamaguchiIkuma KatoIchiro AokiHideaki Nakajima

Published in: Arthritis research & therapy (2018)

The present study reveals that GWAS-identified SNPs contribute to M1 Mφ-predominant inflammation in BD. Our data also suggest that the skewed Mφ polarization is correctable by immunological intervention.

Keyphrases

oxidative stress
genome wide
randomized controlled trial
genome wide association study
adipose tissue
electronic health record
dendritic cells
genome wide association
machine learning
deep learning