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Synthesis and Properties of Oligonucleotides Containing LNA-Sulfamate and Sulfamide Backbone Linkages.

Belma Zengin KurtDebashis DharaAfaf H El-SagheerTom Brown
Published in: Organic letters (2024)
Oligonucleotides hold great promise as therapeutic agents but poor bioavailability limits their utility. Hence, new analogues with improved cell uptake are urgently needed. Here, we report the synthesis and physical study of reduced-charge oligonucleotides containing artificial LNA-sulfamate and sulfamide linkages combined with 2'-O-methyl sugars and phosphorothioate backbones. These oligonucleotides have high affinity for RNA and excellent nuclease resistance.
Keyphrases
  • nucleic acid
  • physical activity
  • single cell
  • mental health
  • cell therapy
  • stem cells
  • big data
  • molecular docking
  • mesenchymal stem cells
  • deep learning