Tom Brown (T Brown)

ResearcherID Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 84

Top Venues

Journal of the American Chemical Society

Journal of medicinal chemistry

Chemical science

Nature communications

University of Oxford

University of Bradford (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Oxford Oct 01 2013

United Kingdom

Professor of Nucleic Acid Chemistry :: Chemistry

University of Southampton Apr 01 1995 - Sep 30 2013

United Kingdom

Professor :: Chemistry

University of Edinburgh Oct 01 1985 - Mar 31 1995

United Kingdom

Professor :: Chemistry

University of Cambridge Mar 01 1982 - Sep 30 1985

United Kingdom

Postdoctoral researcher :: Chemistry

University of Oxford Sep 01 1979 - Feb 28 1982

United Kingdom

Postdoctoral researcher :: Chemistry Dyson Perrins Lab

Education History

University of Bradford Sep 01 1975 - Sep 30 1979

United Kingdom

PHD :: Chemistry

Publications

Roman Belle, Hilal Saraç, Eidarus Salah, Bhaskar Bhushan, Aleksandra Szykowska, Grace Roper, Anthony Tumber, Skirmantas Kriaucionis, Nicola Burgess-Brown, Christopher J Schofield, Tom Brown, Akane Kawamura
Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2-Hydroxyglutarate. Journal of medicinal chemistry 67 (6) (2024)
Cheng Jin, Siqi Li, Katherine A Vallis, Afaf H El-Sagheer, Tom Brown
Modular and automated synthesis of oligonucleotide-small molecule conjugates for cathepsin B mediated traceless release of payloads. RSC chemical biology 5 (8) (2024)
Jianfeng Sun, Martin Philpott, Danson Shek Chun Loi, Shuang Li, Pablo Monteagudo-Mesas, Gabriela Hoffman, Jonathan Robson, Neelam Mehta, Vicki Gamble, Tom Brown, Tom Brown, Stefan Canzar, Udo Oppermann, Adam P Cribbs
Correcting PCR amplification errors in unique molecular identifiers to generate accurate numbers of sequencing molecules. Nature methods (2024)
Jianfeng Sun, Martin Philpott, Danson Shek Chun Loi, Shuang Li, Pablo Monteagudo-Mesas, Gabriela Hoffman, Jonathan Robson, Neelam Mehta, Vicki Gamble, Tom Brown, Tom Brown, Stefan Canzar, Udo Oppermann, Adam P Cribbs
Correcting PCR amplification errors in unique molecular identifiers to generate accurate numbers of sequencing molecules. Nature methods 21 (3) (2024)
Roman Belle, Hilal Saraç, Eidarus Salah, Bhaskar Bhushan, Aleksandra Szykowska, Grace Roper, Anthony Tumber, Skirmantas Kriaucionis, Nicola Burgess-Brown, Christopher J Schofield, Tom Brown, Akane Kawamura
Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2-Hydroxyglutarate. Journal of medicinal chemistry 67 (6) (2024)
Belma Zengin Kurt, Debashis Dhara, Afaf H El-Sagheer, Tom Brown
Synthesis and Properties of Oligonucleotides Containing LNA-Sulfamate and Sulfamide Backbone Linkages. Organic letters (2024)
Roman Belle, Hilal Saraç, Eidarus Salah, Bhaskar Bhushan, Aleksandra Szykowska, Grace Roper, Anthony Tumber, Skirmantas Kriaucionis, Nicola Burgess-Brown, Christopher J Schofield, Tom Brown, Akane Kawamura
Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2-Hydroxyglutarate. Journal of medicinal chemistry 67 (6) (2024)
Rebecca Roddan, William J Nathan, Joseph A Newman, Afaf Helmy El-Sagheer, David M Wilson, Tom Brown, Christopher J Schofield, Peter J McHugh
Molecular insights into the stimulation of SNM1A nuclease activity by CSB during interstrand crosslink processing. bioRxiv : the preprint server for biology (2024)
Roman Belle, Hilal Saraç, Eidarus Salah, Bhaskar Bhushan, Aleksandra Szykowska, Grace Roper, Anthony Tumber, Skirmantas Kriaucionis, Nicola Burgess-Brown, Christopher J Schofield, Tom Brown, Akane Kawamura
Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2-Hydroxyglutarate. Journal of medicinal chemistry (2024)
Belma Zengin Kurt, Debashis Dhara, Afaf H El-Sagheer, Tom Brown
Synthesis and Properties of Oligonucleotides Containing LNA-Sulfamate and Sulfamide Backbone Linkages. Organic letters 26 (19) (2024)
Cheng Jin, Siqi Li, Katherine A Vallis, Afaf H El-Sagheer, Tom Brown
Modular and automated synthesis of oligonucleotide-small molecule conjugates for cathepsin B mediated traceless release of payloads. RSC chemical biology 5 (8) (2024)
Gangshun Yi, Mingda Ye, Loic Carrique, Afaf Helmy El-Sagheer, Tom Brown, Chris J Norbury, Peijun Zhang, Robert C G Gilbert
Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs. Nature structural & molecular biology (2024)
Roman Belle, Hilal Saraç, Eidarus Salah, Bhaskar Bhushan, Aleksandra Szykowska, Grace Roper, Anthony Tumber, Skirmantas Kriaucionis, Nicola Burgess-Brown, Christopher J Schofield, Tom Brown, Akane Kawamura
Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2-Hydroxyglutarate. Journal of medicinal chemistry (2024)
Jianfeng Sun, Martin Philpott, Danson Shek Chun Loi, Shuang Li, Pablo Monteagudo-Mesas, Gabriela Hoffman, Jonathan Robson, Neelam Mehta, Vicki Gamble, Tom Brown, Tom Brown, Stefan Canzar, Udo Oppermann, Adam P Cribbs
Correcting PCR amplification errors in unique molecular identifiers to generate accurate numbers of sequencing molecules. Nature methods 21 (3) (2024)
Belma Zengin Kurt, Debashis Dhara, Afaf H El-Sagheer, Tom Brown
Synthesis and Properties of Oligonucleotides Containing LNA-Sulfamate and Sulfamide Backbone Linkages. Organic letters 26 (19) (2024)
Roman Belle, Hilal Saraç, Eidarus Salah, Bhaskar Bhushan, Aleksandra Szykowska, Grace Roper, Anthony Tumber, Skirmantas Kriaucionis, Nicola Burgess-Brown, Christopher J Schofield, Tom Brown, Akane Kawamura
Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2-Hydroxyglutarate. Journal of medicinal chemistry 67 (6) (2024)
Jianfeng Sun, Martin Philpott, Danson Shek Chun Loi, Shuang Li, Pablo Monteagudo-Mesas, Gabriela Hoffman, Jonathan Robson, Neelam Mehta, Vicki Gamble, Tom Brown, Tom Brown, Stefan Canzar, Udo Oppermann, Adam P Cribbs
Correcting PCR amplification errors in unique molecular identifiers to generate accurate numbers of sequencing molecules. Nature methods 21 (3) (2024)
Belma Zengin Kurt, Debashis Dhara, Afaf H El-Sagheer, Tom Brown
Synthesis and Properties of Oligonucleotides Containing LNA-Sulfamate and Sulfamide Backbone Linkages. Organic letters 26 (19) (2024)
Jianfeng Sun, Martin Philpott, Danson Shek Chun Loi, Shuang Li, Pablo Monteagudo-Mesas, Gabriela Hoffman, Jonathan Robson, Neelam Mehta, Vicki Gamble, Tom Brown, Tom Brown, Stefan Canzar, Udo Oppermann, Adam P Cribbs
Correcting PCR amplification errors in unique molecular identifiers to generate accurate numbers of sequencing molecules. Nature methods 21 (3) (2024)
Roman Belle, Hilal Saraç, Eidarus Salah, Bhaskar Bhushan, Aleksandra Szykowska, Grace Roper, Anthony Tumber, Skirmantas Kriaucionis, Nicola Burgess-Brown, Christopher J Schofield, Tom Brown, Akane Kawamura
Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2-Hydroxyglutarate. Journal of medicinal chemistry 67 (6) (2024)
Gangshun Yi, Mingda Ye, Loic Carrique, Afaf Helmy El-Sagheer, Tom Brown, Chris J Norbury, Peijun Zhang, Robert C G Gilbert
Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs. Nature structural & molecular biology (2024)
Sarah R E Orsborne, Jeffrey Gorman, Leah R Weiss, Akshay Sridhar, Naitik A Panjwani, Giorgio Divitini, Peter Budden, David Palecek, Seán T J Ryan, Akshay Rao, Rosana Collepardo-Guevara, Afaf Helmy El-Sagheer, Tom Brown, Jan Behrends, Richard Henry Friend, Florian Auras
Photogeneration of Spin Quintet Triplet-Triplet Excitations in DNA-Assembled Pentacene Stacks. Journal of the American Chemical Society 145 (9) (2023)
Sarah R E Orsborne, Jeffrey Gorman, Leah R Weiss, Akshay Sridhar, Naitik A Panjwani, Giorgio Divitini, Peter Budden, David Palecek, Seán T J Ryan, Akshay Rao, Rosana Collepardo-Guevara, Afaf Helmy El-Sagheer, Tom Brown, Jan Behrends, Richard Henry Friend, Florian Auras
Photogeneration of Spin Quintet Triplet-Triplet Excitations in DNA-Assembled Pentacene Stacks. Journal of the American Chemical Society 145 (9) (2023)
Sarah R E Orsborne, Jeffrey Gorman, Leah R Weiss, Akshay Sridhar, Naitik A Panjwani, Giorgio Divitini, Peter Budden, David Palecek, Seán T J Ryan, Akshay Rao, Rosana Collepardo-Guevara, Afaf Helmy El-Sagheer, Tom Brown, Jan Behrends, Richard Henry Friend, Florian Auras
Correction to "Photogeneration of Spin Quintet Triplet-Triplet Excitations in DNA-Assembled Pentacene Stacks". Journal of the American Chemical Society (2023)
Sarah R E Orsborne, Jeffrey Gorman, Leah R Weiss, Akshay Sridhar, Naitik A Panjwani, Giorgio Divitini, Peter Budden, David Palecek, Seán T J Ryan, Akshay Rao, Rosana Collepardo-Guevara, Afaf Helmy El-Sagheer, Tom Brown, Jan Behrends, Richard Henry Friend, Florian Auras
Correction to "Photogeneration of Spin Quintet Triplet-Triplet Excitations in DNA-Assembled Pentacene Stacks". Journal of the American Chemical Society (2023)
Sarah R E Orsborne, Jeffrey Gorman, Leah R Weiss, Akshay Sridhar, Naitik A Panjwani, Giorgio Divitini, Peter Budden, David Palecek, Seán T J Ryan, Akshay Rao, Rosana Collepardo-Guevara, Afaf Helmy El-Sagheer, Tom Brown, Jan Behrends, Richard Henry Friend, Florian Auras
Photogeneration of Spin Quintet Triplet-Triplet Excitations in DNA-Assembled Pentacene Stacks. Journal of the American Chemical Society (2023)
Sarah R E Orsborne, Jeffrey Gorman, Leah R Weiss, Akshay Sridhar, Naitik A Panjwani, Giorgio Divitini, Peter Budden, David Palecek, Seán T J Ryan, Akshay Rao, Rosana Collepardo-Guevara, Afaf Helmy El-Sagheer, Tom Brown, Jan Behrends, Richard Henry Friend, Florian Auras
Photogeneration of Spin Quintet Triplet-Triplet Excitations in DNA-Assembled Pentacene Stacks. Journal of the American Chemical Society 145 (9) (2023)
Joseph Hennessy, Piotr Klimkowski, Daniel Singleton, Alex Gibney, Malou Coche, Nicholas P Farrell, Afaf H El-Sagheer, Tom Brown, Andrew Kellett
Thiazole orange-carboplatin triplex-forming oligonucleotide (TFO) combination probes enhance targeted DNA crosslinking. RSC medicinal chemistry 15 (2) (2023)
Sarah R E Orsborne, Jeffrey Gorman, Leah R Weiss, Akshay Sridhar, Naitik A Panjwani, Giorgio Divitini, Peter Budden, David Palecek, Seán T J Ryan, Akshay Rao, Rosana Collepardo-Guevara, Afaf Helmy El-Sagheer, Tom Brown, Jan Behrends, Richard Henry Friend, Florian Auras
Photogeneration of Spin Quintet Triplet-Triplet Excitations in DNA-Assembled Pentacene Stacks. Journal of the American Chemical Society 145 (9) (2023)
Joseph Hennessy, Piotr Klimkowski, Daniel Singleton, Alex Gibney, Malou Coche, Nicholas P Farrell, Afaf H El-Sagheer, Tom Brown, Andrew Kellett
Thiazole orange-carboplatin triplex-forming oligonucleotide (TFO) combination probes enhance targeted DNA crosslinking. RSC medicinal chemistry 15 (2) (2023)
Shankar Pandey, Shankar Mandal, Mathias Bogetoft Danielsen, Asha Brown, Changpeng Hu, Niels Johan Christensen, Alina Vitaliyivna Kulakova, Shixi Song, Tom Brown, Knud Jørgen Jensen, Jesper Wengel, Chenguang Lou, Han-Bin Mao
Chirality transmission in macromolecular domains. Nature communications 13 (1) (2022)
Tom Brown, Bengt Nordén
Nobel Prize 2022 to Sharpless, Meldal, Bertozzi Click Chemistry - molecular lego. Quarterly reviews of biophysics 55 (2022)
Cheng Jin, Afaf H Ei-Sagheer, Siqi Li, Katherine A Vallis, Weihong Tan, Tom Brown
Engineering Enzyme-Cleavable Oligonucleotides by Automated Solid-Phase Incorporation of Cathepsin B Sensitive Dipeptide Linkers. Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 134 (13) (2022)
Cheng Jin, Afaf H Ei-Sagheer, Siqi Li, Katherine A Vallis, Weihong Tan, Tom Brown
Engineering Enzyme-Cleavable Oligonucleotides by Automated Solid-Phase Incorporation of Cathepsin B Sensitive Dipeptide Linkers. Angewandte Chemie (International ed. in English) 61 (13) (2022)
Sven Epple, Afaf Helmy El-Sagheer, Tom Brown
Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology. Emerging topics in life sciences 5 (5) (2022)
Anna Dysko, Ysobel R Baker, Graham McClorey, Matthew J A Wood, Sabine Fenner, Glynn Williams, Afaf El-Sagheer, Tom Brown
Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides. RSC chemical biology 3 (6) (2022)
Ysobel R Baker, Cameron Thorpe, Jinfeng Chen, Laura M Poller, Lina Cox, Pawan Kumar, Wooi Fang Lim, Lillian Lie, Graham McClorey, Sven Epple, Daniel Singleton, Michael A McDonough, Jack S Hardwick, Kirsten E Christensen, Matthew John Andrew Wood, James P Hall, Afaf Helmy El-Sagheer, Tom Brown
An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides. Nature communications 13 (1) (2022)
Cheng Jin, Afaf H Ei-Sagheer, Siqi Li, Katherine A Vallis, Weihong Tan, Tom Brown
Engineering Enzyme-Cleavable Oligonucleotides by Automated Solid-Phase Incorporation of Cathepsin B Sensitive Dipeptide Linkers. Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 134 (13) (2022)
Chunsen Bai, Piotr Klimkowski, Cheng Jin, Jagannath Kuchlyan, Afaf H El-Sagheer, Tom Brown
A new phosphoramidite enables orthogonal double labelling to form combination oligonucleotide probes. Organic & biomolecular chemistry 20 (44) (2022)
Maria-Eleni Kyriazi, Afaf Helmy El-Sagheer, Igor L Medintz, Tom Brown, Antonios G Kanaras
An Investigation into the Resistance of Spherical Nucleic Acids against DNA Enzymatic Degradation. Bioconjugate chemistry 33 (1) (2022)
Konstantina Alexaki, Maria Eleni Kyriazi, Joshua Greening, Lapatrada Taemaitree, Afaf Helmy El-Sagheer, Tom Brown, Xunli Zhang, Otto L Muskens, Antonios G Kanaras
A SARS-Cov-2 sensor based on upconversion nanoparticles and graphene oxide. RSC advances 12 (29) (2022)
Martin Philpott, Jonathan Watson, Anjan Thakurta, Tom Brown, Tom Brown, Udo Oppermann, Adam P Cribbs
Nanopore sequencing of single-cell transcriptomes with scCOLOR-seq. Nature biotechnology (2021)
Miguel Xavier, Maria-Eleni Kyriazi, Stuart Lanham, Konstantina Alexaki, Elloise Matthews, Afaf Helmy El-Sagheer, Tom Brown, Antonios G Kanaras, Richard O C Oreffo
Enrichment of Skeletal Stem Cells from Human Bone Marrow Using Spherical Nucleic Acids. ACS nano 15 (4) (2021)
Sven Epple, Cameron Thorpe, Ysobel R Baker, Afaf Helmy El-Sagheer, Tom Brown
Consecutive 5'- and 3'-amide linkages stabilise antisense oligonucleotides and elicit an efficient RNase H response. Chemical communications (Cambridge, England) 56 (41) (2021)
Anders Foller Füchtbauer, Moa S Wranne, Sangamesh Sarangamath, Mattias Bood, Afaf Helmy El-Sagheer, Tom Brown, Henrik Gradén, Morten Grøtli, L Marcus Wilhelmsson
Lighting Up DNA with the Environment-Sensitive Bright Adenine Analogue qAN4. ChemPlusChem 85 (2) (2021)
Damien J Downes, Robert A Beagrie, Matthew E Gosden, Jelena Telenius, Stephanie J Carpenter, Lea Nussbaum, Sara De Ornellas, Martin Sergeant, Chris Q Eijsbouts, Ron Schwessinger, Jon Kerry, Nigel A Roberts, Arun Shivalingam, Afaf Helmy El-Sagheer, A Marieke Oudelaar, Tom Brown, Veronica J Buckle, James O J Davies, Jim R Hughes
High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale. Nature communications 12 (1) (2021)
Shifali Shishodia, Marina Demetriades, Dong Zhang, Nok Yin Tam, Pratheesh Maheswaran, Caitlin Clunie-O'Connor, Anthony Tumber, Ivanhoe K H Leung, Yi Min Ng, Thomas M Leissing, Afaf Helmy El-Sagheer, Eidarus Salah, Tom Brown, Wei Shen Aik, Michael A McDonough, Christopher J Schofield
Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors. Journal of medicinal chemistry 64 (22) (2021)
Bengt Nordén, Tom Brown, Bobo Feng
Mismatch detection in homologous strand exchange amplified by hydrophobic effects. Biopolymers 112 (4) (2021)
Angela Federica De Fazio, Doxi Misatziou, Ysobel R Baker, Otto L Muskens, Tom Brown, Antonios G Kanaras
Chemically modified nucleic acids and DNA intercalators as tools for nanoparticle assembly. Chemical Society reviews 50 (23) (2021)
Jeffrey Gorman, Sarah R E Orsborne, Akshay Sridhar, Raj Pandya, Peter Budden, Alexander Ohmann, Naitik A Panjwani, Yun Liu, Jake L Greenfield, Simon Dowland, Victor Gray, Seán T J Ryan, Sara De Ornellas, Afaf Helmy El-Sagheer, Tom Brown, Jonathan R Nitschke, Jan Behrends, Ulrich Felix Keyser, Akshay Rao, Rosana Collepardo-Guevara, Eugen Stulz, Richard Henry Friend, Florian Auras
Deoxyribonucleic Acid Encoded and Size-Defined π-Stacking of Perylene Diimides. Journal of the American Chemical Society 144 (1) (2021)
Sven Epple, Aman Modi, Ysobel R Baker, Ewa Wȩgrzyn, Diallo Traoré, Przemyslaw Wanat, Agnes E S Tyburn, Arun Shivalingam, Lapatrada Taemaitree, Afaf Helmy El-Sagheer, Tom Brown
A New 1,5-Disubstituted Triazole DNA Backbone Mimic with Enhanced Polymerase Compatibility. Journal of the American Chemical Society 143 (39) (2021)
Ysobel R Baker, Liyiwen Yuan, Jinfeng Chen, Roman Belle, Robert Carlisle, Afaf Helmy El-Sagheer, Tom Brown
Expanding the chemical functionality of DNA nanomaterials generated by rolling circle amplification. Nucleic acids research 49 (16) (2021)
Alisina Bazrafshan, Maria-Eleni Kyriazi, Brandon Alexander Holt, Wenxiao Deng, Selma Piranej, Hanquan Su, Yuesong Hu, Afaf Helmy El-Sagheer, Tom Brown, Gabriel A Kwong, Antonios G Kanaras, Khalid Salaita
DNA Gold Nanoparticle Motors Demonstrate Processive Motion with Bursts of Speed Up to 50 nm Per Second. ACS nano 15 (5) (2021)
Nicoló Zuin Fantoni, Afaf Helmy El-Sagheer, Tom Brown
A Hitchhiker's Guide to Click-Chemistry with Nucleic Acids. Chemical reviews 121 (12) (2021)
Luciana M Oliveira, Adam S Long, Tom Brown, Keith R Fox, Gerald Weber
Melting temperature measurement and mesoscopic evaluation of single, double and triple DNA mismatches. Chemical science 11 (31) (2020)
Arun Shivalingam, Lapatrada Taemaitree, Afaf Helmy El-Sagheer, Tom Brown
Squaramides and Ureas: A Flexible Approach to Polymerase-Compatible Nucleic Acid Assembly. Angewandte Chemie (International ed. in English) 59 (28) (2020)
Martin R Gill, Michael G Walker, Sarah Able, Ole Tietz, Abirami Lakshminarayanan, Rachel Anderson, Rod Chalk, Afaf H El-Sagheer, Tom Brown, James A Thomas, Katherine A Vallis
An 111In-labelled bis-ruthenium(ii) dipyridophenazine theranostic complex: mismatch DNA binding and selective radiotoxicity towards MMR-deficient cancer cells. Chemical science 11 (33) (2020)
Nicoló Zuin Fantoni, Bríonna McGorman, Zara Molphy, Daniel Singleton, Sarah Walsh, Afaf Helmy El-Sagheer, Vickie McKee, Tom Brown, Andrew Kellett
Development of Gene-Targeted Polypyridyl Triplex-Forming Oligonucleotide Hybrids. Chembiochem : a European journal of chemical biology 21 (24) (2020)
A Marieke Oudelaar, Robert A Beagrie, Matthew E Gosden, Sara De Ornellas, Emily Georgiades, Jon Kerry, Daniel Hidalgo, Joana Carrelha, Arun Shivalingam, Afaf Helmy El-Sagheer, Jelena M Telenius, Tom Brown, Veronica J Buckle, Merav Socolovsky, Douglas R Higgs, Jim R Hughes
Dynamics of the 4D genome during in vivo lineage specification and differentiation. Nature communications 11 (1) (2020)
Piotr Klimkowski, Sara De Ornellas, Daniel Singleton, Afaf Helmy El-Sagheer, Tom Brown
Design of thiazole orange oligonucleotide probes for detection of DNA and RNA by fluorescence and duplex melting. Organic & biomolecular chemistry 17 (24) (2019)
Lapatrada Taemaitree, Arun Shivalingam, Afaf H El-Sagheer, Tom Brown
An artificial triazole backbone linkage provides a split-and-click strategy to bioactive chemically modified CRISPR sgRNA. Nature communications 10 (1) (2019)
William Doherty, Eva-Maria Dürr, Hannah T Baddock, Sook Y Lee, Peter J McHugh, Tom Brown, Elisabeth Sitte, Eoin M Scanlan, Joanna F McGouran
A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A. Organic & biomolecular chemistry 17 (35) (2019)
Adam M Thomas, Sanja Brolih, Joanna F McGouran, Afaf Helmy El-Sagheer, Denis Ptchelkine, Morgan Jones, Neil Q McDonald, Peter J McHugh, Tom Brown
Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors. Chemical communications (Cambridge, England) 55 (78) (2019)
Martin R Gill, Bas M Bavelaar, Philip A Waghorn, Martin R Gill, Afaf H El-Sagheer, Tom Brown, Madalena Tarsounas, Katherine A Vallis
Radiolabeled Oligonucleotides Targeting the RNA Subunit of Telomerase Inhibit Telomerase and Induce DNA Damage in Telomerase-Positive Cancer Cells. Cancer research 79 (18) (2019)
Angela F De Fazio, Afaf Helmy El-Sagheer, Jason S Kahn, Iris Nandhakumar, Matthew Richard Burton, Tom Brown, Otto L Muskens, Oleg Gang, Antonios G Kanaras
Light-Induced Reversible DNA Ligation of Gold Nanoparticle Superlattices. ACS nano 13 (5) (2019)
Huili Wang, Yun Zhang, Rongxing Li, Jinfang Nie, Afaf H El-Sagheer, Tom Brown, Zhaoying Liu, Wencheng Xiao
Instrument-free quantitative gold nanoparticle-based liquid-phase colorimetric assays for use in resource-poor environments. Chemical communications (Cambridge, England) 53 (60) (2018)
Maria Moros, Maria-Eleni Kyriazi, Afaf Helmy El-Sagheer, Tom Brown, Claudia Tortiglione, Antonios G Kanaras
DNA-Coated Gold Nanoparticles for the Detection of mRNA in Live Hydra Vulgaris Animals. ACS applied materials & interfaces 11 (15) (2018)
Johanna Midelet, Afaf Helmy El-Sagheer, Tom Brown, Antonios G Kanaras, Anne Débarre, Martinus H V Werts
Spectroscopic and Hydrodynamic Characterisation of DNA-Linked Gold Nanoparticle Dimers in Solution using Two-Photon Photoluminescence. Chemphyschem : a European journal of chemical physics and physical chemistry 19 (7) (2018)
Christopher P Lawson, Anders Foller Füchtbauer, Moa S Wranne, Tristan Giraud, Thomas Floyd, Blaise Dumat, Nicolai K Andersen, Afaf H El-Sagheer, Tom Brown, Henrik Gradén, L Marcus Wilhelmsson, Morten Grøtli
Synthesis, oligonucleotide incorporation and fluorescence properties in DNA of a bicyclic thymine analogue. Scientific reports 8 (1) (2018)
Mattias Bood, Anders Foller Füchtbauer, Moa S Wranne, Jong Jin Ro, Sangamesh Sarangamath, Afaf Helmy El-Sagheer, Déborah L M Rupert, Rachel S Fisher, Steven W Magennis, Anita C Jones, Fredrik Höök, Tom Brown, Byeang Hyean Kim, Anders Dahlén, L Marcus Wilhelmsson, Morten Grøtli
Pentacyclic adenine: a versatile and exceptionally bright fluorescent DNA base analogue. Chemical science 9 (14) (2018)
Jinfeng Chen, Ysobel R Baker, Asha Brown, Afaf Helmy El-Sagheer, Tom Brown
Enzyme-free synthesis of cyclic single-stranded DNA constructs containing a single triazole, amide or phosphoramidate backbone linkage and their use as templates for rolling circle amplification and nanoflower formation. Chemical science 9 (42) (2018)
Julia Piccoli, Robert Hein, Afaf Helmy El-Sagheer, Tom Brown, Eduardo M Cilli, Paulo R Bueno, Jason J Davis
Redox Capacitive Assaying of C-Reactive Protein at a Peptide Supported Aptamer Interface. Analytical chemistry 90 (5) (2018)
Sarah Walsh, Afaf Helmy El-Sagheer, Tom Brown
Fluorogenic thiazole orange TOTFO probes stabilise parallel DNA triplexes at pH 7 and above. Chemical science 9 (39) (2018)
Pawan Kumar, Afaf H El-Sagheer, Lynda Truong, Tom Brown
Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA. Chemical communications (Cambridge, England) 53 (63) (2018)
Maria-Eleni Kyriazi, Davide Giust, Afaf Helmy El-Sagheer, Peter M Lackie, Otto L Muskens, Tom Brown, Antonios G Kanaras
Multiplexed mRNA Sensing and Combinatorial-Targeted Drug Delivery Using DNA-Gold Nanoparticle Dimers. ACS nano 12 (4) (2018)
Davide Giust, María Isabel Lucío, Afaf Helmy El-Sagheer, Tom Brown, Lorraine E Williams, Otto L Muskens, Antonios G Kanaras
Graphene Oxide-Upconversion Nanoparticle Based Portable Sensors for Assessing Nutritional Deficiencies in Crops. ACS nano 12 (6) (2018)
Arun Shivalingam, Agnes E S Tyburn, Afaf H El-Sagheer, Tom Brown
Molecular Requirements of High-Fidelity Replication-Competent DNA Backbones for Orthogonal Chemical Ligation. Journal of the American Chemical Society 139 (4) (2017)
Françoise S Howe, Andrew Russell, Anna R Lamstaes, Afaf Helmy El-Sagheer, Anitha Nair, Tom Brown, Jane Mellor
CRISPRi is not strand-specific at all loci and redefines the transcriptional landscape. eLife 6 (2017)
Moa S Wranne, Anders Foller Füchtbauer, Blaise Dumat, Mattias Bood, Afaf Helmy El-Sagheer, Tom Brown, Henrik Gradén, Morten Grøtli, L Marcus Wilhelmsson
Toward Complete Sequence Flexibility of Nucleic Acid Base Analogue FRET. Journal of the American Chemical Society 139 (27) (2017)
Mikiembo Kukwikila, Nittaya Gale, Afaf H El-Sagheer, Tom Brown, Ali Tavassoli
Assembly of a biocompatible triazole-linked gene by one-pot click-DNA ligation. Nature chemistry 9 (11) (2017)
Jack S Hardwick, Denis Ptchelkine, Afaf H El-Sagheer, Ian Tear, Daniel Singleton, Simon E V Phillips, Andrew N Lane, Tom Brown
5-Formylcytosine does not change the global structure of DNA. Nature structural & molecular biology 24 (6) (2017)
A Plochowietz, A H El-Sagheer, Tom Brown, A N Kapanidis
Stable end-sealed DNA as robust nano-rulers for in vivo single-molecule fluorescence. Chemical science 7 (7) (2016)
Wenjing Meng, Richard A Muscat, Mireya L McKee, Phillip J Milnes, Afaf H El-Sagheer, Jonathan Bath, Benjamin G Davis, Tom Brown, Rachel K O'Reilly, Andrew J Turberfield
An autonomous molecular assembler for programmable chemical synthesis. Nature chemistry 8 (6) (2016)
Patrick Vilela, Afaf El-Sagheer, Timothy M Millar, Tom Brown, Otto L Muskens, Antonios G Kanaras
Graphene Oxide-Upconversion Nanoparticle Based Optical Sensors for Targeted Detection of mRNA Biomarkers Present in Alzheimer's Disease and Prostate Cancer. ACS sensors 2 (1) (2016)

Tom Brown.css-eqlu8i{font-size:small;padding-left:4px;} (T Brown)

Publication Activity (10 Years)

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Tom Brown (T Brown)