Genetic compensation response could exist in colorectal cancer: UPF3A upregulates the oncogenic homologue gene SRSF3 expression corresponding to SRSF6 to promote colorectal cancer metastasis.

Weimin XuWeijun OuYuan FengQingru XuYili YangLong CuiPeng Du

Published in: Journal of gastroenterology and hepatology (2023)

GCR may exist in CRC and exert effects on the progression of CRC. Targeted inhibition of UPF3A could reduce the GCR effects and suppress the expression of oncogenic homologue genes corresponding to PTC mutations, indicating a novel therapeutic strategy for treatment of CRC metastasis.

Keyphrases

poor prognosis
genome wide
transcription factor
copy number
binding protein
long non coding rna
cancer therapy
gene expression