B cell activation gene signature in blood and liver of HBeAg+ immune active chronic hepatitis B patients.
Zgjim OsmaniBoris J B BeudekerZwier M A GroothuisminkRobert J de KnegtRaymond T ChungJeroen AerssensJacques BollekensHarry L A JanssenAdam J GehringGeorg M LauerAlex K ShalekHarmen J G van de WerkenAndré BoonstraPublished in: The Journal of infectious diseases (2024)
Our data show a distinctive B cell activation gene signature in the blood of immune active chronic HBV patients, characterized by a significant upregulation of immune-related genes, including IRF1, STAT1, STAT3, TAP1, and TAPBP. This peripheral activation profile was also observed in B cells from the liver by single cell RNA-seq showing upregulation of IRF1, CD83 and significantly higher CD69 expression, with naive and memory B cell subsets being the primary carriers of the signature. Our findings suggest that B cell gene profiles reflect responsiveness to HBV infection, these findings are relevant for clinical studies evaluating immunomodulatory treatment strategies for HBV.
Keyphrases
- hepatitis b virus
- rna seq
- single cell
- end stage renal disease
- poor prognosis
- ejection fraction
- newly diagnosed
- cell proliferation
- chronic kidney disease
- copy number
- liver failure
- prognostic factors
- immune response
- machine learning
- signaling pathway
- dendritic cells
- high throughput
- long non coding rna
- drug induced
- artificial intelligence