Reduction of Senescence Associated Secretory Phenotype and exosome-shuttled miRNAs by Haritaki fruit extract in senescent dermal fibroblasts.

Patrick BogdanowiczNicolas RoulletPaul BensadounSandrine Bessou-TouyaJean-Marc LemaitreHélène Duplan

Published in: International journal of cosmetic science (2023)

Haritaki strongly reduced SASP expression and EV-shuttled miRNAs in senescent fibroblasts. These results indicate that Haritaki has strong senomorphic properties and may be a promising ingredient for the development of new anti-aging dermo-cosmetic products by inhibiting deleterious effects of senescent cells.

Keyphrases

induced apoptosis
poor prognosis
extracellular matrix
cell cycle arrest
signaling pathway
oxidative stress
dna damage
stress induced
anti inflammatory
endoplasmic reticulum stress
cell proliferation