ORMDL3 overexpression facilitates FcεRI-mediated transcription of proinflammatory cytokines and thapsigargin-mediated PERK phosphorylation in RBL-2H3 cells.

Kazuhiro OgiTetsuji TakabayashiKaori TomitaMasafumi SakashitaTaiyo MorikawaTakahiro NinomiyaMasayuki OkamotoNorihiko NaritaShigeharu Fujieda

Published in: Immunity, inflammation and disease (2021)

Our findings suggest that ORMDL3 plays an important role in regulating proinflammatory cytokine expression via the S1P pathway and selectively affects the UPR pathway in mast cells.

Keyphrases

induced apoptosis
poor prognosis
endoplasmic reticulum stress
transcription factor
cell cycle arrest
cell proliferation
binding protein
long non coding rna
pi k akt