Diet Supplementation with Fish-Derived Extracts Suppresses Diabetes and Modulates Intestinal Microbiome in a Murine Model of Diet-Induced Obesity.
Konstantinos AxarlisMaria G DaskalakiSofia MichailidouNikolais AndroulakiAntiopi TsourekiEvangelia MouchtaropoulouOurania KolliniatiIoanna LapiEirini DermitzakiMaria VenihakiKaterina C KousoulakiAnagnostis ArgiriouZouhir El MarsniChristos TsatsanisPublished in: Marine drugs (2021)
Metabolic syndrome-related diseases affect millions of people worldwide. It is well established that changes in nutritional habits and lifestyle can improve or prevent metabolic-related pathologies such as type-2 diabetes and obesity. Previous reports have shown that nutritional supplements have the capacity to limit glucose intolerance and suppress diabetes development. In this study, we investigated the effect of dietary supplementation with fish-derived extracts on obesity and type 2 diabetes and their impact on gut microbial composition. We showed that nutritional supplements containing Fish Complex (FC), Fish Complex combined with Cod Powder (FC + CP), or Cod Powder combined with Collagen (CP + C) improved glucose intolerance, independent of abdominal fat accumulation, in a mouse model of diet-induced obesity and type 2 diabetes. In addition, collagen-containing supplements distinctly modulate the gut microbiome in high-fat induced obesity in mice. Our results suggest that fish-derived supplements suppress diet-induced type 2 diabetes, which may be partly mediated through changes in the gut microbiome. Thus, fish-derived supplements and particularly the ones containing fish collagen have potential beneficial properties as dietary supplements in managing type 2 diabetes and metabolic syndrome via modulation of the gut microbiome.
Keyphrases
- type diabetes
- metabolic syndrome
- insulin resistance
- glycemic control
- high fat diet induced
- weight loss
- cardiovascular disease
- mouse model
- adipose tissue
- uric acid
- physical activity
- blood pressure
- signaling pathway
- risk assessment
- cardiovascular risk factors
- body mass index
- drug induced
- high resolution
- tissue engineering
- endothelial cells
- fatty acid
- high glucose
- single molecule
- human health
- atomic force microscopy