Genome-Wide CRISPR Screen Identifies an NF2-Adherens Junction Mechanistic Dependency for Cardiac Lineage.
Mick Chang Jie LeeMatias Ilmari AutioWen Hao ZhengYoohyun SongShyi Chyi WangDarren Chen Pei WongJingwei XiaoYike ZhuPermeen YusoffXi YeiWan Kee ChockBoon Chuan LowMarius SudolRoger S-Y FooPublished in: Circulation (2024)
These results provide mechanistic insight into the essential role of NF2 during early epithelial-mesenchymal transition by sequestering the repressive effect of YAP and relieving regulatory roadblocks en route to cardiomyocytes.
Keyphrases
- genome wide
- signaling pathway
- epithelial mesenchymal transition
- dna methylation
- lps induced
- pi k akt
- nuclear factor
- copy number
- oxidative stress
- high throughput
- left ventricular
- transcription factor
- inflammatory response
- single cell
- gene expression
- crispr cas
- heart failure
- genome editing
- cell proliferation
- immune response
- atrial fibrillation
- high glucose