PSD-95 Protein: A Promising Therapeutic Target in Chronic Pain.
Lulin MaDongdong SunSong WenJie YuanJing LiXinran TanSong CaoPublished in: Molecular neurobiology (2024)
Chronic pain, as a social public health problem, has a serious impact on the quality of patients' life. Currently, the main drugs used to treat chronic pain are opioids, antipyretic, and nonsteroidal anti-inflammatory drugs (NSAIDs). But the obvious side effects limit their use, so it is urgent to find new therapeutic targets. Postsynaptic density (PSD)-95 protein plays an important role in the occurrence and development of chronic pain. The over-expression of the PSD-95 protein and its interaction with other proteins are closely related to the chronic pain. Besides, the PSD-95-related drugs that inhibit the expression of PSD-95 as well as the interaction with other protein have been proved to treat chronic pain significantly. In conclusion, although more deep studies are needed in the future, these studies indicate that PSD-95 and the related proteins, such as NMDA receptor (NMDAR) subunit 2B (GluN2B), AMPA receptor (AMPAR), calmodulin-dependent protein kinase II (CaMKII), 5-hydroxytryptamine 2A receptor (5-HT2AR), and neuronal nitric oxide synthase (nNOS), are the promising therapeutic targets for chronic pain.
Keyphrases
- chronic pain
- pain management
- binding protein
- public health
- nitric oxide synthase
- protein kinase
- poor prognosis
- protein protein
- amino acid
- anti inflammatory drugs
- nitric oxide
- healthcare
- risk assessment
- newly diagnosed
- end stage renal disease
- ejection fraction
- small molecule
- prognostic factors
- mental health
- patient reported outcomes
- case control