Thymopentin alleviates premature ovarian failure in mice by activating YY2/Lin28A and inhibiting the expression of let-7 family microRNAs.

Wei YangFangyuan JingPeirong HuangZixiang GengJianghong XuJiahui LiDanping ChenYing ZhuZhenxin WangWillian HuangChuan Chen

Published in: Cell proliferation (2021)

Thymopentin promotes the transcriptional activation of Lin28A via stimulating transcription factor YY2 expression, inhibits the activity of let-7 family microRNAs and alleviates the ageing of ovarian granulosa cells, ultimately achieving a therapeutic effect on POF in mice.

Keyphrases

transcription factor
poor prognosis
signaling pathway
induced apoptosis
high fat diet induced
gene expression
binding protein
type diabetes
long non coding rna
metabolic syndrome
insulin resistance
dna binding
cell death
skeletal muscle
heat shock