Analysis of the Immunoexpression of Opioid Receptors and their Correlation with Markers of Angiogenesis, Cell Proliferation and Apoptosis in Breast Cancer.
Alceu Machado De SousaThinali Sousa DantasPaulo Goberlânio de Barros SilvaConceição Da Silva MartinsGildenio Estevam FreireHoward Lopes Ribeiro JuniorGerly Anne De Castro BritoKaruza Maria Alves PereiraRenata Ferreira De Carvalho LeitãoPublished in: Asian Pacific journal of cancer prevention : APJCP (2021)
The κ-opioid receptor has a lower immunoexpression in nodal tumor metastasis with recurrence, whereas the μ-opioid receptor is directly related to expression of TUNEL-positive cells in tumors and indirectly to Ki-67 in nodal metastasis. Neither of the two receptors was expressed in the primary tumor or nodal metastasis in relation to VEGF.
Keyphrases
- chronic pain
- pain management
- neoadjuvant chemotherapy
- cell cycle arrest
- cell proliferation
- lymph node
- vascular endothelial growth factor
- endothelial cells
- induced apoptosis
- poor prognosis
- cell death
- oxidative stress
- pi k akt
- binding protein
- cell cycle
- young adults
- free survival
- long non coding rna
- locally advanced
- rectal cancer