Modified Mesenchymal stem cell, platelet-rich plasma, and hyaluronic acid intervention in early stage osteoarthritis: A systematic review, meta-analysis, and meta-regression of arthroscopic-guided intra-articular approaches.
Kevin Christian TjandraRobin NovriansyahI Nyoman Sebastian SudiasaArdiyana ArNurul Azizah Dian RahmawatiIsmail Hadisoebroto DilogoPublished in: PloS one (2024)
Arthroscopic guided high-dose subchondral application of primary cultured synovial MSCs in popliteal PRP media with HA effectively regenerates cartilage defects and improves clinical outcomes in early-stage osteoarthritis. Clarification of MSC sources and quantities enhances the understanding of this promising treatment modality.
Keyphrases
- platelet rich plasma
- early stage
- hyaluronic acid
- mesenchymal stem cells
- high dose
- systematic review
- rheumatoid arthritis
- rotator cuff
- umbilical cord
- randomized controlled trial
- knee osteoarthritis
- anterior cruciate ligament reconstruction
- low dose
- bone marrow
- meta analyses
- endothelial cells
- squamous cell carcinoma
- stem cells
- smoking cessation