Zishen Pill alleviates diabetes in Db/db mice via activation of PI3K/AKT pathway in the liver.

You WuBoju SunXiaoyuan GuoLili WuYaomu HuLingling QinTao YangMei LiTianyu QinMiao JiangTong-Hua Liu

Published in: Chinese medicine (2022)

ZSP treatment reduced the severity of diabetic symptoms in db/db mice. ZSP increased expression of genes associated with glycogen synthesis and glycolysis, and decreased gluconeogenesis via the enhancement of the PI3K/AKT signaling in the liver.

Keyphrases

type diabetes
high fat diet induced
poor prognosis
cardiovascular disease
mouse model
insulin resistance
wild type
glycemic control
adipose tissue
weight loss