Genetics of Alzheimer's Disease.
Jong Hun KimPublished in: Dementia and neurocognitive disorders (2019)
Alzheimer's disease (AD) related genes have been elucidated by advanced genetic techniques. Familial autosomal dominant AD genes founded by linkage analyses are APP, PSEN1, PSEN2, ABCA7, and SORL1. Genome-wide association studies have found risk genes such as ABCA7, BIN1, CASS4, CD33, CD2AP, CELF1, CLU, CR1, DSG2, EPHA1, FERMT2, HLA-DRB5-HLA-DRB1, INPP5D, MEF2C, MS4A6A/MS4A4E, NME8, PICALM, PTK2B, SLC24A4, SORL1, and ZCWPW1. ABCA7, SORL1, TREM2, and APOE are proved to have high odds ratio (>2) in risk of AD using next generation sequencing studies. Thanks to the promising genetic techniques such as CRISPR-CAS9 and single-cell RNA sequencing opened a new era in genetics. CRISPR-CAS9 can directly link genetic knowledge to future treatment. Single-cell RNA sequencing are providing useful information on cell biology and pathogenesis of diverse diseases.
Keyphrases
- single cell
- genome wide
- crispr cas
- rna seq
- genome editing
- early onset
- copy number
- high throughput
- cognitive decline
- dna methylation
- mass spectrometry
- multiple sclerosis
- genome wide association
- ms ms
- healthcare
- case control
- transcription factor
- high fat diet
- gene expression
- mesenchymal stem cells
- genome wide identification
- cell therapy
- type diabetes
- stem cells
- human immunodeficiency virus
- metabolic syndrome